Journal
CURRENT MEDICINAL CHEMISTRY
Volume 26, Issue 34, Pages 6321-6338Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867326666190704121309
Keywords
Extracellular matrix; stem cell; interaction; proliferation; differentiation; engineering
Funding
- Fostering Talents of National Natural Science Foundation of China [U1504310]
- Fostering Talents of National Natural Science Foundation of Henan Province [U1504310]
- Key Scientific Research Projects of Higher Education Institutions in Henan Province [16A430030]
- Key Project and Special Foundation of Research, Development and Promotion in Henan Province [182102310076]
- Top Doctor Program of Zhengzhou University [32210475]
- Joint Fund for Fostering Talents of NCIR-MMT [MMT2017-01]
- Joint Fund for Fostering Talents of HNKL-MMT [MMT2017-01]
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Stem cell transplantation is an advanced medical technology, which brings hope for the treatment of some difficult diseases in the clinic. Attributed to its self-renewal and differential ability, stem cell research has been pushed to the forefront of regenerative medicine and has become a hot topic in tissue engineering. The surrounding extracellular matrix has physical functions and important biological significance in regulating the life activities of cells, which may play crucial roles for in situ inducing specific differentiation of stem cells. In this review, we discuss the stem cells and their engineering application, and highlight the control of the fate of stem cells, we offer our perspectives on the various challenges and opportunities facing the use of the components of extracellular matrix for stem cell attachment, growth, proliferation, migration and differentiation.
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