Journal
CURRENT MEDICINAL CHEMISTRY
Volume 27, Issue 6, Pages 854-902Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867326666190726123229
Keywords
TiO2 nanotubes; drug delivery; growth factors; statins; flavonoids; inorganic ions; nanoparticles; antibiotics; osseointegration
Funding
- UE-FISCDI [PN-III-P4-ID-PCE-2016-0691, PN-III-P2-2.1-PED-2016-1372]
Ask authors/readers for more resources
TiO2 nanotubes (TNTs) are attractive nanostructures for localized drug delivery. Owing to their excellent biocompatibility and physicochemical properties, numerous functionalizations of TNTs have been attempted for their use as therapeutic agent delivery platforms. In this review, we discuss the current advances in the applications of TNT-based delivery systems with an emphasis on the various functionalizations of TNTs for enhancing osteogenesis at the bone-implant interface and for preventing implant-related infection. Innovation of therapies for enhancing osteogenesis still represents a critical challenge in regeneration of bone defects. The overall concept focuses on the use of osteoconductive materials in combination with the use of osteoinductive or osteopromotive factors. In this context, we highlight the strategies for improving the functionality of TNTs, using five classes of bioactive agents: growth factors (GFs), statins, plant derived molecules, inorganic therapeutic ions/nanoparticles (NPs) and antimicrobial compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available