Journal
CRYSTAL GROWTH & DESIGN
Volume 19, Issue 7, Pages 4070-4080Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.cgd.9b00473
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Funding
- New York University Materials Research Science and Engineering Center (MRSEC) program of the National Science Foundation [DMR-1420073]
- National Science Foundation [DMR-1608374]
- NSF Chemistry Research Instrumentation and Facilities Program [CHE-0840277]
- DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357]
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Trimorphic paracetamol, one of the most commonly used analgesic and antipyretic drugs, has been a model system for studying transformations among phases of molecular crystalline materials. During crystallization from the melt and the glass above 0 degrees C, three new polymorphs of paracetamol (N-acetyl-para-aminophenol or acetaminophen) were discovered, doubling the number of known ambient forms. The crystal structure of one new form was solved using a combination of powder X-ray diffraction and computational techniques. Growth kinetics became anomalous near the glass transition: as temperature decreased, growth rate increased; this rare and poorly understood phenomenon is commonly identified as the glass-to-crystal (GC) growth mode. In addition, two polymorphs displayed optical evidence of helicoidal morphologies, a characteristic of at least 25% of molecular crystals, that has been resistant to a universal explanation.
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