Journal
BIOMATERIALS
Volume 53, Issue -, Pages 669-678Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.02.113
Keywords
7-Hydroxy coumarin; Mitochondria-targeted; Ratiometric; pH probe; Real time
Funding
- National Program on Key Basic Research Project of China (973 Program) [2012CB720603, 2013CB328900]
- National Science Foundation of China [21232005, 21472131, J1310008, J1103315]
- Specialized Research Fund for the Doctoral Program of Higher Education in China [20120181130006]
- State Key Lab of Oral Diseases (Sichuan University) [SKLODOF2014OF01]
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Pyridinium functioned 7-hydroxy coumarin was presented as the first mitochondria-targeted ratiometric fluorescent probe CP for real time monitoring pH in living cells. Compared with commercially available mitochondrial trackers, CP possesses high specificity to mitochondria in living cells as well as good biocompatibility. Meanwhile, CP displays excellent pH sensitivity and anti-interference capability. Confocal image experiments confirm that CP can monitor mitochondrial pH changes associated with the mitochondrial acidification, cellular apoptosis and stress response efficiently in real time. (C) 2015 Elsevier Ltd. All rights reserved.
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