Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 179, Issue -, Pages 429-436Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2019.04.029
Keywords
Magnesium alloy; Corrosion resistance; Antibacterial performance; Hydroxyapatite coating; Layer-by-layer assembly
Funding
- National Natural Science Foundation of China [51571134]
- Shandong University of Science and Technology (SDUST) Research Fund [2014TDJH104]
- Shandong Provincial Natural Science Foundation [ZR2017BEM002]
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As a result of their good biocompatibility, bioactivity, and mechanical properties, magnesium (Mg) alloys have received considerable attention as next generation biodegradable implants. Herein, in order to achieve a proper degradation rate and good antibacterial ability, we reported a novel hydroxyapatite coating induced by gentamicin (GS)-loaded polymeric multilayers for the surface treatment of the Mg alloy. The coating was characterized by X-ray diffraction, fourier transform infrared spectroscopy and scanning electron microscopy. The as prepared hydroxyapatite coating showed the compact morphology and a well-crystallized apatite structure. This coating could improve the adhesion strength and reduce the corrosion rate of the substrate in simulated body fluid solution. Meanwhile, the drug release and antibacterial experiments demonstrated that the GS loaded specimen revealed a significant antimicrobial performance toward Staphylococcus minus and had a prolonged release profile of GS, which would be helpful to the long-term bactericidal activity of the Mg implant. This coating showed acceptable biocompatibility via MTT assay and Live/dead staining. Thus, the multilayers-hydroxyapatite coated Mg alloy could improve the corrosion resistance and biocompatibility while delivering vital drugs to the site of implantation.
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