Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 178, Issue -, Pages 337-345Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2019.03.020
Keywords
Pulmonary surfactant; Curosurf((R)); Cryo-electron microscopy; Bio-nano interfaces; Magnetic wires; Microrheology
Funding
- ANR (Agence Nationale de la Recherche)
- CGI (Commissariat a l'Investissement d'Avenir) through Labex SEAM (Science and Engineering for Advanced Materials and devices) [ANR 11 LABX 086, ANR 11 IDEX 05 02]
- French National Research Agency [ANR-10-INSB-04]
- Agence Nationale de la Recherche [ANR-13-BS08-0015, ANR-12-CHEX-0011, ANR-15-CE18-0024-01, ANR-17CE09-0017]
- Solvay.in
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The role of pulmonary surfactant is to reduce the surface tension in the lungs and to facilitate breathing. Surfactant replacement therapy (SRT) aims at bringing a substitute by instillation into the airways, a technique that has proven to be efficient and lifesaving for preterm infants. Adapting this therapy to adults requires to scale the administered dose to the patient body weight and to increase the lipid concentration, whilst maintaining its surface and flow properties similar. Here, we exploit a magnetic wire-based microrheology technique to measure the viscosity of the exogenous pulmonary surfactant Curosurf((R)) in various experimental conditions. The Curosurf((R)) viscosity is found to increase exponentially with lipid concentration following the Krieger-Dougherty law of colloids. The Krieger-Dougherty behavior also predicts a divergence of the viscosity at the liquid-to-gel transition. For Curosurf((R)) the transition concentration is found close to the concentration at which it is formulated (117 g L-1 versus 80 g L-1). This outcome suggests that for SRT the surfactant rheological properties need to be monitored and kept within a certain range. The results found here could help in producing suspensions for respiratory distress syndrome adapted to adults. The present work also demonstrates the potential of the magnetic wire microrheology technique as an accurate tool to explore biological soft matter dynamics.
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