Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 179, Issue -, Pages 519-526Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2019.04.007
Keywords
Self-assembled; Amphiphilic chitosan; Quercetin; Nanomicelles; Efficient delivery
Funding
- Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences [1630122017011, 1630122018009, 1630122019013]
- Science and technology projects of Zhanjiang [2018A02015]
- Natural Science Foundation of Guangdong Province [2018A030307015, 2018A030313109]
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Quercetin (QCT) has important functions such as antioxidant, anti-inflammatory and anticancer. However, its applications in food and in drug are restricted owing to its poor water solubility. In this work, a novel amphiphilic wall-material chitosan was synthesized via grafting of chitosan with deoxycholic acid (DA) as hydrophobic group and modified N-acetyl-L-cysteine (NAC) as hydrophilic group. Amphiphilic chitosan was self-assembled to load QCT as nanomicelles by a low-cost and inorganic solvent procedure. Both the encapsulation efficiencies (EE) and drug-loading rates (DL) increased when increasing the grafting rate of DA. There was a bursting release of QCT for the QCT-loaded nanomicelles (CS-DA-NAC-QNMs) from 0 to 8 h, and then the release rate decreased gradually. After releasing for 72 h, the final cumulative release percentages were more than 40%. All the QCT-loaded nanomicelles samples showed good hemocompatibility, and their water solubility and biocompatibility increased evidently. What's more, they exhibited an obvious inhibition rate of A549 cells.
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