Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 572, Issue -, Pages 307-316Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2019.04.012
Keywords
Pluronic F-127; Temperature sensitive; Semi-IPN hydrogels; Silver composites
Categories
Funding
- Fondecyt [3170272, 300061, 11160073]
- Universidad de Talca, Talca, Chile
- CIPA, CONICYT Regional, GORE BIO-BIO [R17A10003]
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This investigation aims to develop bacterial-resistant temperature-sensitive semi-IPN silver composite hydrogels via a three-step method. Primarily, the temperature-sensitive semi-IPN hydrogels of N-isopropylacrylamide and various concentrations of Pluronic F-127 (PF 127), have been prepared via a free radical polymerization technique. Furthermore, silver ions were encapsulated in the temperature-sensitive semi-IPN hydrogels via the swelling process. Finally, the bacterial-resistant semi-IPN silver composite hydrogels were developed by using an aqueous neem extract as a reducing agent. Semi-IPN hydrogels with higher amount of PF-127 showed a water uptake that was three times better than the pristine poly (N-isopropylacrylamide). The phase transition temperature of the semi-IPN silver composite hydrogels was found to be 34.24 degrees C, which was confirmed from the swelling and the DSC studies. The resulting hydrogels were characterized by: FTIR, UV-vis, X-ray diffraction, SEM and TEM analyses. The TEM results confirmed the fact that the nanoparticles formed were of spherical shape with a dimension of (similar to)8 +/- 2 nm. The semi-IPN silver-composite hydrogels showed excellent bacteria inhibition against gram-positive bacteria. The results demonstrated that the temperature-sensitive semi-IPN silver-composite hydrogels developed can be employed for clinical applications.
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