Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 570, Issue -, Pages 182-190Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2019.03.021
Keywords
Calix[4]resorcinarene; PEG; Conjugation; SAXS; Encapsulation
Categories
Funding
- Kazan Federal University [4.1493.2017/4.6, 4.5151.2017/6.7]
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The synthesis and study of self-association and encapsulation ability of new low toxic conjugate of tetraphenyleneoxypentylcalix[4]resorcinarene and methoxy-poly(ethylene glycole) (C5OPh-mPEG) were described. The conjugate is characterized by H-1, C-13 NMR, FT-IR, MS, SLS methods. In an aqueous solution the conjugate form multimicellar nanoparticles with low polydispersity value (0.1, DLS method). The self-association of the conjugate was studied by DLS, fluorescence, fluorescence anisotropy method, TEM, and SAXS methods. The SAXS data were detailed analyzed, and the conjugate associates structure as ellipsoidal core-shell particles was proposed. The encapsulation efficiency is a result of the affinity of the conjugate low rim substituents to substrates and reaches of 39.8, 26.7, and 28.9% toward naproxen, ibuprofen and doxorubicin drugs, respectively.
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