Journal
BIOMATERIALS
Volume 39, Issue -, Pages 206-217Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.11.009
Keywords
MoS2 nanosheets; Controllable; Bottom-up; Photothermal regression; Tumor
Funding
- National Basic Research Program of China (973 Program) [2011CB707905]
- China National Funds for Distinguished Young Scientists [51225202]
- National Natural Science Foundation of China [51072212]
- Program of Shanghai Subject Chief Scientist [14XD1403800]
- China Postdoctoral Science Foundation [2014M551463]
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Two-dimensional transition metal dichalcogenides, particularly MoS2 nanosheets, have been deemed as a novel category of NIR photothermal transducing agent. Herein, an efficient and versatile one-pot solvothermal synthesis based on bottom-up strategy has been, for the first time, proposed for the controlled synthesis of PEGylated MoS2 nanosheets by using a novel integrated precursor containing both Mo and S elements. This facile but unique PEG-mediated solvothermal procedure endowed MoS2 nanosheets with controlled size, increased crystallinity and excellent colloidal stability. The photothermal performance of nanosheets was optimized via modulating the particulate size and surface PEGylation. PEGylated MoS2 nanosheets with desired photothermal conversion performance and excellent colloidal and photothermal stability were further utilized for highly efficient photothermal therapy of cancer in a tumor-bearing mouse xenograft. Without showing observable in vitro and in vivo hemolysis, coagulation and toxicity, the optimized MoS2-PEG nanosheets showed promising in vitro and in vivo anti-cancer efficacy. (C) 2014 Elsevier Ltd. All rights reserved.
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