Journal
BIOMATERIALS
Volume 38, Issue -, Pages 10-21Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.10.065
Keywords
Fe3O4@Au nanostars; Hyaluronic acid; CT imaging; MR imaging; Tumors; Photothermal therapy
Funding
- National Natural Science Foundation of China [21273032, 81101150, 81371623]
- Fund of the Science and Technology Commission of Shanghai Municipality [11nm0506400, 12520705500]
- Sino-German Center for Research Promotion [GZ899]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
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Development of multifunctional theranostic nanoplatforms for diagnosis and therapy of cancer still remains a great challenge. In this work, we report the use of hyaluronic acid-modified Fe3O4@Au core/shell nanostars (Fe3O4@Au-HA NSs) for tri-mode magnetic resonance (MR), computed tomography (CT), and thermal imaging and photothermal therapy of tumors. In our approach, hydrothermally synthesized Fe3O4@Ag nanoparticles (NPs) were used as seeds to form Fe3O4@Au NSs in the growth solution. Further sequential modification of polyethyleneimine (PEI) and HA affords the NSs with excellent colloidal stability, good biocompatibility, and targeting 'specificity to CD44 receptor-overexpressing cancer cells. With the Fe3O4 core NPs and the star-shaped Au shell, the formed Fe3O4@Au-HA NSs are able to be used as a nanoprobe for efficient MR and CT imaging of cancer cells in vitro and the xenografted tumor model in vivo. Likewise, the NIR absorption property enables the developed Fe3O4@Au-HA NSs to be used as a nanoprobe for thermal imaging of tumors in vivo and photothermal ablation of cancer cells in vitro and xenografted tumor model in vivo. This study demonstrates a unique multifunctional theranostic nanoplatform for multi-mode imaging and photothermal therapy of tumors, which may find applications in theranostics of different types of cancer. (C) 2014 Elsevier Ltd. All rights reserved.
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