Journal
CIRCULATION JOURNAL
Volume 83, Issue 10, Pages 2044-2048Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-19-0118
Keywords
Atherosclerosis; Cataracts; Carotid intima-media thickness; Circadian rhythm; Epidemiology
Categories
Funding
- Department of Indoor Environmental Medicine, Nara Medical University
- JSPS KAKENHI [24790774, 22790567, 25860447, 25461393, 15H04776, 10124877]
- Mitsui Sumitomo Insurance Welfare Foundation
- Meiji Yasuda Life Foundation of Health and Welfare
- Osaka Gas Group Welfare Foundation
- Japan Diabetes Foundation
- Daiwa Securities Health Foundation
- Japan Science and Technology Agency
- YKK AP Inc.
- Ushio Inc.
- Nara Prefecture Health Promotion Foundation
- Nara Medical University Grant-in-Aid for Collaborative Research Projects
- Tokyo Electric Power Company
- EnviroLife Research Institute Co., Ltd.
- Sekisui Chemical Co., Ltd
- LIXIL Corp.
- KYOCERA Corp.
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Background: Decreased light reception because of cataracts leads to potential circadian misalignment, resulting in exacerbation of atherosclerosis; however, little is known about the association between cataracts and atherosclerosis in populations. Methods and Results: In this cross-sectional study, cataracts were graded using slit lamp biomicroscopy with the Lens Opacities Classification System III and carotid atherosclerosis was assessed based on carotid intima-media thickness (IMT) measured using ultrasonography of the common carotid artery in 442 elderly participants (mean age, 70.0 years). Cataract was defined as nuclear cataract grade >= 3.0, cortical cataract grade >= 2.0, or posterior subcapsular cataract grade >= 2.0 in both eyes. The mean and maximal carotid IMT was 0.86 +/- 0.15 mm and 1.07 +/- 0.29 mm, respectively. In multivariable analysis adjusted for potential confounders, the mean and maximal carotid IMT were significantly greater in the cataract group than in the non-cataract group by 0.04 mm (95% confidence interval (CI), 0.01-0.06) and 0.07mm (95% CI 0.01-0.12), respectively. Logistic regression analysis adjusted for confounders revealed a significantly higher odds ratio for carotid atherosclerosis (maximal carotid IMT >= 1.1 mm) in the cataract group than in the non-cataract group (odds ratio, 1.78; 95% CI, 1.14-2.78). Conclusions: Cataracts may be independently associated with subclinical carotid atherosclerosis in the elderly population, indicating a need for further prospective studies.
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