Journal
CHINESE CHEMICAL LETTERS
Volume 30, Issue 10, Pages 1731-1737Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.05.022
Keywords
Small-molecule fluorophores; The second near-infrared channel; Benzo-bisthiadiazole; Biomedical imaging
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Funding
- NKRDPC [2016YFD0200902]
- National Natural Science Foundation of China [21708012]
- 111 Project [B17019]
- NSFHP [2017CFB151]
- self-determined research funds of CCNU from the colleges, basic research and operation of MOE for the Central Universities [110030106190234]
- Wuhan Morning Light Plan of Youth Science and Technology [201705304010321]
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In the second near-infrared channel (NIR-II, 1000-1700 nm), organic and inorganic fluorophores are designed with superior chemical/optical properties to provide real-time information with deeper penetration depth and higher resolution owing to the innate lower light scattering and absorption of the NIR-II imaging than conventional optical imaging. Among them, the small-molecule based fluorophores have been highlighted due to their desirable biocompatibility and favorable pharmacokinetics. In this review, we introduced the latest research progress of the rational design of small-molecule NIR-II fluorophores and their impressively biological applications including the NIR-II signal imaging, multimodal imaging and theranostic. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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