Journal
CHINESE CHEMICAL LETTERS
Volume 31, Issue 3, Pages 859-864Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.06.032
Keywords
Peptide-Au bioconjugates; PNIPAM nanoparticles; Fluorescence; Drug delivery; Cell imaging
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Funding
- National Natural Science Foundation of China (NSFC) [51573013, 51873016]
- China Scholarship Council (CSC)
- Shaanxi Natural Science Foundation [2018JM2004]
- NSFC [21705129]
- Helmholtz association, program Science and Technology of Nanosystems (STN)
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A facile and efficient strategy has been developed to fabricate a multifunctional, theranostic anticancer drug delivery platform featuring active targeting, controlled drug release and fluorescence imaging for real-time control of delivery. To this end, thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) nanospheres are decorated with peptide-Au cluster conjugates as a smart nanomedicine platform. A sophisticated trifunctional peptide is designed to release the anticancer drug doxorubicin (DOX), target cells and reduce Au3+ ions to form luminescent Au clusters. Importantly, the peptide-Au cluster moieties are attached to the PNIPAM nanospheres via amide bonds rather than noncovalent interactions, significantly improving their stability in biological medium and drug release efficiency. The in vitro experiments showed that DOX was released in an efficient and controlled manner under physiological conditions. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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