Journal
CHINESE CHEMICAL LETTERS
Volume 30, Issue 10, Pages 1689-1703Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.04.017
Keywords
Near-infrared fluorescent dyes; Photodynamic therapy; Cyanine; BODIPY; Phthalocyanine
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Funding
- Natural Science Foundation Committee of China (NSFC) [81671803]
- National Key Research and Development Program [2017YFC0107700]
- Outstanding Youth Foundation of Jiangsu Province [GX20171114003, BK20170030]
- Fok Ying Tung Education Foundation [161033]
- Double First-Class University Project [CPU2018GY06, CPU2018GY24]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Natural Science Foundation of China [21676113, 21402057, 21772054, 21472059]
- Hubei Province [2018CFA079]
- 111 Project [B17019]
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Photodynamic therapy (PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared (NIR) fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) analogues, phthalocyanine and other agents such as rhodamine analogues. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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