Journal
CHINESE CHEMICAL LETTERS
Volume 31, Issue 3, Pages 787-791Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.05.025
Keywords
Hydrogen sulfide; Near-infrared light; Photothermal transduction; Nanocomposite hydrogels; Anti-inflammation
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Funding
- National Natural Science Foundation of China [21735002, 21575037, 21778016, 21675046, 21877030]
- Natural Science Foundation of Hunan Province [2177JJ3026]
- Keypoint Research and Invention Program of Hunan Province [2017DK2011]
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A novel near-infrared light photothemal-activated H2S-donating nanocomposite hydrogel was developed, through combination of a thermo-labile H2S donor and photothermal nanoparticles in agarose hydrogel. The polyethylenimine dithiocarbamate polymer, a thermo-labile compound, was synthesized as a novel H2S donor. The combination of a thermo-labile hydrogen sulfide donor and photothermal nanoparticles enabled the generation of H2S in agarose hydrogel upon irradiation with near-infrared light. The ability to modulate the photoirradiation for controlled generation and spatiotemporally release of H2S are its specific advantages. This photothermal spatiotemporally controlled H2S-releasing strategy was successfully applied to anti-inflammation treatment in a rat model, demonstrating its utility as a novel H2S-based therapeutic approach. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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