Journal
CHINESE CHEMICAL LETTERS
Volume 30, Issue 10, Pages 1704-1716Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.06.039
Keywords
Fluorescent probe; Protein vicinal dithiols; Arsenical probe; Thiol redox; Reaction-based probe
Categories
Funding
- National Natural Science Foundation of China [21572093, 21778028]
- 111 Project
Ask authors/readers for more resources
The vicinal dithiol motif is widely present in proteins, and is critical for proteins' structures and functions. In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes. Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available