Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 50, Pages 11630-11634Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201902918
Keywords
alkoxyl radical; C-H activation; cross-coupling; dual catalysis; photoredox catalyst
Categories
Funding
- EPFL (Switzerland)
- Swiss National Science Foundation (SNSF) [200021-178846/1]
- Swiss National Science Foundation (SNF) [200021_178846] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
The reaction of readily available and bench-stable N-alkoxypyridinium salts with arylboronic and vinylboronic acids afforded delta-aryl and delta-vinyl alcohols, respectively, in the presence of fac-Ir(ppy)(3) and Cu(OTf)(2) dual catalysts. The reaction takes place through a domino process involving the reductive generation of alkoxyl radicals, 1,5-hydrogen atom transfer (1,5-HAT) and the copper-catalyzed cross-coupling reaction of the resulting translocated carbon radicals with boronic acids. Complementary to the Minisci reaction, this method allows for the arylation of nucleophilic alkyl radicals with both electron-rich and electron-poor arenes under mild reaction conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available