Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 5, Pages 964-979Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201901961
Keywords
flagella; interactions; motility; natural products; quorum sensing
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Funding
- Emmy Noether program of the Deutsche Forschungsgemeinschaft (DFG)
- EU FP7 Marie Curie Zukunftskolleg Incoming Fellowship
- Konstanz Research School Chemical Biology (KoRS-CB)
- KoRS-CB PhD fellowship
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Bacteria can migrate in groups of flagella-driven cells over semisolid surfaces. This coordinated form of motility is called swarming behavior. Swarming is associated with enhanced virulence and antibiotic resistance of various human pathogens and may be considered as favorable adaptation to the diverse challenges that microbes face in rapidly changing environments. Consequently, the differentiation of motile swarmer cells is tightly regulated and involves multi-layered signaling networks. Controlling swarming behavior is of major interest for the development of novel anti-infective strategies. In addition, compounds that block swarming represent important tools for more detailed insights into the molecular mechanisms of the coordination of bacterial population behavior. Over the past decades, there has been major progress in the discovery of small-molecule modulators and mechanisms that allow selective inhibition of swarming behavior. Herein, an overview of the achievements in the field and future directions and challenges will be presented.
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