Journal
CHEMISTRY OF MATERIALS
Volume 31, Issue 11, Pages 4291-4298Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.9b01530
Keywords
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Funding
- National Key R&D Program of China [2018YFC1602301, 2018YFA0209402]
- National Natural Science Foundation of China [21373059]
- Science & Technology Commission of Shanghai Municipality [16DZ2270100]
- Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- NHMRC Senior Principal Research Fellowship [GNT1135806]
- National 1000 Youth Talents Program of China
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SiO2 nanotubes (NTs), with uniform diameter (similar to 25 nm) and tailored shell thickness (1-5 nm), and featuring chemically asymmetric surfaces (a silane-functionalized exterior surface and a negatively charged (-Si-O-) interior surface) are prepared by a facile, template-free approach. Owing to their chemically asymmetric properties, positively charged cargoes can be selectively loaded with high content into the SiO2 NTs via electrostatic interaction. Mediated by polyamidoamine dendrimers preassembled in the NTs, different noble metal nanoparticles can be selectively deposited inside the NTs with high density and uniform size. Owing to their high specific surface area and elongated pore structure with lengths up to several micrometers, the SiO2 NTs exhibit a high loading capacity (80 wt %) for positively charged therapeutic agents, which exhibit sustained cargo release properties on the order of several months if the NTs are assembled into a membrane structure.
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