Journal
CHEMICAL ENGINEERING JOURNAL
Volume 365, Issue -, Pages 358-368Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.02.037
Keywords
Large-mesoporous silica; Mixed functionalization; Anti-cancer drugs; On-off controlled release
Categories
Funding
- Science and Technology Foundation of Guangdong Province [2016A050502044, 2016A010103024, 2015B020237009, 2016B090913004]
- National Nature Science Foundation of China [51603074]
- International Science and Technology Cooperation Project of Guangzhou Economic Technological Development Zone [2017GH09]
- Guangzhou Tianhe District science and technology planning project [201706YG083]
- Guangdong Provincial Natural Science Foundation [2016A030313602]
- Hunan Provincial Innovation Foundation for Postgraduate [CX2016B068]
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Cancer is one of the most concerned diseases in the world, where there is still no reported specifically targeted drugs with high effect. In this study, mesoporous silica with a large pore size of 25.25 nm and magnetic cores was prepared as a carrier of doxorubicin for anti-cancer drug delivery. Besides its superior biocompatibility properties and functional surface, the large mesopores provided enough space for multiple chemical modification and in-situ growth of Au nanoparticles. Amino groups were grafted on the inner mesopores to capture the drug molecules via complexation. Cooperated with the steric hindrance of beta-Cyclodextrin (beta-CD) on the external surface, a perfect response to acid environment was established. Meanwhile, the presence of magnetic cores and Au nanoparticles gave the system sensitive response to both alternating magnetic field (AMF) and near infrared ray (NIR). What's more, the combination of magnetic cores and Au nanoparticles provided a strong medical nuclear magnetic resonance (NMR) signal with a linear correlation of 0.9946. The accurate dose related NMR signal and the multi-stimuli sensitive response, including pH, AMF and NIR, make this system immense potential for imaging diagnosis and targeted drug delivery therapy.
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