Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 76, Issue 18, Pages 3525-3542Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03138-w
Keywords
Natural peptides; Rational design; Human diseases; Human viruses; Drugs
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil
- Fundacao de Amparo a Pesquisa do Distrito Federal (FAPDF)
- Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)
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While scientific advances have led to large-scale production and widespread distribution of vaccines and antiviral drugs, viruses still remain a major cause of human diseases today. The ever-increasing reports of viral resistance and the emergence and re-emergence of viral epidemics pressure the health and scientific community to constantly find novel molecules with antiviral potential. This search involves numerous different approaches, and the use of antimicrobial peptides has presented itself as an interesting alternative. Even though the number of antimicrobial peptides with antiviral activity is still low, they already show immense potential to become pharmaceutically available antiviral drugs. Such peptides can originate from natural sources, such as those isolated from mammals and from animal venoms, or from artificial sources, when bioinformatics tools are used. This review aims to shed some light on antimicrobial peptides with antiviral activities against human viruses and update the data about the already well-known peptides that are still undergoing studies, emphasizing the most promising ones that may become medicines for clinical use.
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