Journal
CELLULAR & MOLECULAR BIOLOGY LETTERS
Volume 24, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s11658-019-0173-x
Keywords
miR211; EZRIN; Osteosarcoma; Cell viability; Cell apoptosis
Categories
Funding
- Science and Technology Department Health Joint Fund Project of Fujian Province [2018 J01388]
- National Natural Science Foundation of China [81201893]
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BackgroundIn recent years, microRNA-211 (miR211) has been considered as a tumor suppressor in multiple malignancies. However, the function of miR211 in human osteosarcoma has not been explored intensively so far. In this study, the relationship between miR211 and EZRIN was analyzed in human osteosarcoma.MethodsThe expression levels of miR211 and EZRIN were measured in both human osteosarcoma cells and tissues. The direct regulatory relationship between miR211 and EZRIN was evaluated using dual-luciferase assay. The effect of miR211 and EZRIN overexpression on cell proliferation, migration/invasion, and apoptosis was detected.ResultsThe expression of miR211 was obviously lower in osteosarcoma tissues than paracancerous tissues. EZRIN was identified as the direct target of miR211, and up-regulation of miR211 increased the percentage of cell apoptosis, and suppressed cell proliferation as well as cell migration/invasion via directly regulating EZRIN.ConclusionsOur study indicated that miR211 has an important role in the development and progress of osteosarcoma, and it might become a novel target in the diagnosis and treatment of human osteosarcoma.
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