Journal
CELL METABOLISM
Volume 30, Issue 1, Pages 14-15Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2019.06.012
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Funding
- National Cancer Institute [R35CA209896, P01CA087497, R01CA204232]
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Ferroptosis is a form of regulated cell death involving lethal peroxidation of phospholipids (Hirschhorn and Stockwell, 2019). Recent results reveal that ferroptosis mediates the tumor suppressive activity of interferon gamma secreted by CD8(+) T cells in response to immune checkpoint blockade, suggesting the immune system may function in part through ferroptosis to prevent tumorigenesis (Wang et al., 2019).
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