Journal
CELL METABOLISM
Volume 30, Issue 2, Pages 319-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2019.05.022
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Funding
- Ministry of Science and Technology of the People's Republic of China [2016YFC1304803, 2017YFA0503404]
- National Natural Science Foundation of China [31625014, 31621063, 31830040]
- Beijing Advanced Innovation Center for Structural Biology
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Asprosin is a fasting-induced hormone that promotes glucose production in the liver and stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). However, the bona fide receptor of Asprosin is unclear. Here, we have identified that the olfactory receptor OLFR734 acts as a receptor of Asprosin to modulate hepatic glucose production. Olfr734 knockout mice show a blunted response to Asprosin, including attenuated cAMP levels and hepatic glucose production, and improved insulin sensitivity. As Olfr734 deficiency dramatically attenuates both fasting and high-fat-diet-induced glucose production, our results demonstrate a critical role of OLFR734 as a receptor of Asprosin to maintain glucose homeostasis during fasting and in obesity.
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