4.8 Editorial Material

Membrane Cholesterol Regulates Macrophage Plasticity in Cancer

Journal

CELL METABOLISM
Volume 29, Issue 6, Pages 1238-1240

Publisher

CELL PRESS
DOI: 10.1016/j.cmet.2019.05.011

Keywords

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Funding

  1. Italian Association for Cancer Research (AIRC) [IG 19885, IG 20085]
  2. Italian Association for Cancer Research (AIRC 5x100 project) [22757]
  3. Fondazione Cariplo, Italy
  4. Italian Ministry of Education, Universities and Research, Italy (MIUR) [2015YYKPNN_004, 2017BA9LM5]

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The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of crossregulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.

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