Journal
CELL METABOLISM
Volume 29, Issue 6, Pages 1238-1240Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2019.05.011
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Funding
- Italian Association for Cancer Research (AIRC) [IG 19885, IG 20085]
- Italian Association for Cancer Research (AIRC 5x100 project) [22757]
- Fondazione Cariplo, Italy
- Italian Ministry of Education, Universities and Research, Italy (MIUR) [2015YYKPNN_004, 2017BA9LM5]
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The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of crossregulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.
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