Related references
Note: Only part of the references are listed.WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
Woo-Jeong Jeong et al.
NATURE COMMUNICATIONS (2019)
β-Catenin-RAS interaction serves as a molecular switch for RAS degradation via GSK3β
Sang-Kyu Lee et al.
EMBO REPORTS (2018)
Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of beta-catenin signaling
Wookjin Shin et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2018)
Induced Quiescence of Lgr5+Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells
Onur Basak et al.
CELL STEM CELL (2017)
Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1
Yu Zhong et al.
TOXICOLOGIC PATHOLOGY (2016)
A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis
Masayuki Fujii et al.
CELL STEM CELL (2016)
G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway
Shih-Ting Cha et al.
NATURE CELL BIOLOGY (2016)
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation
Pu-Hyeon Cha et al.
NATURE CHEMICAL BIOLOGY (2016)
KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer
Yong-Hee Cho et al.
ONCOTARGET (2016)
The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
Vicki Plaks et al.
CELL STEM CELL (2015)
Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer
Melissa R. Junttila et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion
Hugo J. Snippert et al.
EMBO REPORTS (2014)
Role of Oncogenic K-Ras in Cancer Stem Cell Activation by Aberrant Wnt/β-Catenin Signaling
Byoung-San Moon et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)
KRAS and Cancer Stem Cells in APC-Mutant Colorectal Cancer
Eric R. Fearon et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)
Targeting cancer stem cells to suppress acquired chemotherapy resistance
S. J. Vidal et al.
ONCOGENE (2014)
Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis
Qing Chen et al.
PLOS ONE (2014)
Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis
Woo-Jeong Jeong et al.
SCIENCE SIGNALING (2012)
Not So Lonely at the Top for Cancer Stem Cells
Ann Zeuner et al.
CELL STEM CELL (2011)
The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
Anna Merlos-Suarez et al.
CELL STEM CELL (2011)
Mutant Kras Promotes Hyperplasia and Alters Differentiation in the Colon Epithelium but Does Not Expand the Presumptive Stem Cell Pool
Ying Feng et al.
GASTROENTEROLOGY (2011)
Crypt stem cells as the cells-of-origin of intestinal cancer
Nick Barker et al.
NATURE (2009)
Wnt/β-Catenin is essential for intestinal Homeostasis and maintenance of intestinal stem cells
Tea Fevr et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani et al.
NATURE (2007)
Oncogenic K-ras stimulates wnt signaling in colon cancer through inhibition of GSK-3β
JN Li et al.
GASTROENTEROLOGY (2005)
Wnt signalling induces maturation of Paneth cells in intestinal crypts
JH van Es et al.
NATURE CELL BIOLOGY (2005)
The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis
DC Chung
GASTROENTEROLOGY (2000)
Share Paper
