Journal
CELL CALCIUM
Volume 80, Issue -, Pages 117-124Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2019.04.006
Keywords
TRPV6 channel; Cancer; Cell signaling; Targeting
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Significant advances have been made during last two decades as to the discovery of TRPV6 channel expression in various tissues and particularly in cancer. Among them are the cancers of the epithelial origin such as of prostate, breast, pancreas, ovaries, endometrium, testicule, colon, and lung. Though its role in cancer cell survival, proliferation, and apoptosis resistance was already established both in vitro and in vivo, much less was done in the studying of the downstream pathways where TRPV6 channel is involved which are restricted so far to the Ca2+- calmodulin - calcineurin - NFaT pathways. Finally, in addition to the establishment of its role in human pathophysiology, the first pharmacological approaches were undertaken to target this channel and are described here in detail.
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