Journal
CELL
Volume 177, Issue 6, Pages 1436-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2019.05.009
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Funding
- European Research Council (ERC)
- government of Cataluna (SGR grant)
- government of Spain (MINECO)
- Fundacion Botin and Banco Santander through Santander Universities
- EMBO long-term fellowship
- Juan de la Cierva fellowship from the Spanish MINECO
- la Caixa INPhINIT Fellowship Grant for Doctoral Studies at Spanish Research Centers of Excellence, la Caixa'' Foundation, Barcelona [100010434]
- European Union [713673]
- MINECO grant
- MMRES fellowship from the Barcelona Institute of Science and Technology (BIST)
- Japan Society for the Promotion of Science (JSPS)
- NIH-NINDS [T32 5T32NS045540]
- MINECO
- ProCNIC Foundation
- MINECO award [SEV-2015-0505]
- MINECO (Government of Spain)
- [LCF/BQ/IN17/11620018]
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Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1 -dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Small-dependent clocks, and a memory branch using other Bmal1-dependent clocks to remember time in the absence of external cues.
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