4.8 Editorial Material

Senescence Evasion in Chemotherapy: A Sweet Spot for p21

Journal

CELL
Volume 178, Issue 2, Pages 267-269

Publisher

CELL PRESS
DOI: 10.1016/j.cell.2019.06.025

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Funding

  1. NIGMS NIH HHS [T32 GM142607, T32 GM008759] Funding Source: Medline

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Time-lapse imaging reveals a nuanced role for p21 in cancer cells challenged with chemotherapeutic drugs: cells with either high or low p21 are biased toward senescence, whereas intermediate p21 allows cells to re-enter the cell cycle after drug treatment.

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