Journal
CELL
Volume 178, Issue 3, Pages 567-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2019.06.030
Keywords
-
Categories
Funding
- Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID)
- National Human Genome Research Institute
- Bill and Melinda Gates Foundation [OPP1162123]
- NIH [OD019994, R21 1R21AI138024-01A1, R01AI140891, DA039543, R01AI120961]
- International AIDS Vaccine Initiative's (IAVI's) Neutralizing Antibody Consortium
- NSF [DGE-1256082]
- Swedish Research Council
- US Department of Energy, Basic Energy Sciences, Office of Science [W-31-109-Eng-38]
- Simons Foundation [SF349247]
- NYSTAR
- NIH National Institute of General Medical Sciences [GM103310]
- Agouron Institute [F00316]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [ZIBHG000196] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZICAI005103, ZICAI005111, ZIAAI005024, ZIAAI005095, ZICAI005002, ZIGAI005099, ZICAI005114] Funding Source: NIH RePORTER
- Bill and Melinda Gates Foundation [OPP1162123] Funding Source: Bill and Melinda Gates Foundation
Ask authors/readers for more resources
The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1 strains has been a long-standing goal. To understand how broadly neutralizing antibodies (bNAbs) can be elicited, we identified, characterized, and tracked five neutralizing Ab lineages targeting the HIV-1-fusion peptide (FP) in vaccinated macaques over time. Genetic and structural analyses revealed two of these lineages to belong to a reproducible class capable of neutralizing up to 59% of 208 diverse viral strains. B cell analysis indicated each of the five lineages to have been initiated and expanded by FP-carrier priming, with envelope (Env)-trimer boosts inducing cross-reactive neutralization. These Abs had binding-energy hotspots focused on FP, whereas several FP-directed Abs induced by immunization with Env trimer-only were less FP-focused and less broadly neutralizing. Priming with a conserved subregion, such as FP, can thus induce Abs with binding-energy hotspots coincident with the target subregion and capable of broad neutralization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available