Journal
BIOMATERIALS
Volume 42, Issue -, Pages 20-29Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.11.043
Keywords
Chitin; 2-Hydroxy-3-methacryloyloxypropylated carboxymethyl chitin; Adhesion; Chitin nanofiber
Funding
- Tottori prefectural-financed aid project for beauty & healthy products
- [22550197]
- [25410227]
- Grants-in-Aid for Scientific Research [26708026] Funding Source: KAKEN
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Novel biological adhesives made from chitin derivatives were prepared and evaluated for their adhesive properties and biocompatibility. Chitin derivatives with acrylic groups, such as 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin), were synthesized and cured by the addition of an aqueous hydrogen peroxide solution as a radical initiator. The adhesive strength of HMA-CM-chitin increased when it was blended with chitin nanofibers (CNFs) or surface-deacetylated chitin nanofibers (S-DACNFs). HMA-CM-chitin/CNFs or HMA-CM-chitin/S-DACNFs have almost equal adhesive strength compared to that of a commercial cyanoacrylate adhesive. Moreover, quick adhesion and induction of inflammatory cells migration were observed in HMA-CM-chitin/CNF and HMA-CM-chitin/S-DACNF. These findings indicate that the composites prepared in this study are promising materials as new biological adhesives. (C) 2014 Elsevier Ltd. All rights reserved.
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