Journal
CARDIOVASCULAR RESEARCH
Volume 115, Issue 9, Pages 1385-1392Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvz166
Keywords
Atherosclerosis; Vascular; Inflammation; Immune system; Metabolism
Categories
Funding
- Swedish Heart-Lung Foundation
- Novo Nordisk Foundation [NNF15CC0018346]
- NWO (VICI)
- European Research Council (ERC-con)
- DFG [SFB1123]
- CVON consortium GENIUS-II
- Swedish Research Council [2014-2312]
- Swedish Heart and Lung Foundation [20150600, 20150683]
- NWO [91615052]
- Netherlands Heart Foundation [2013T003, 2017T048]
- CCA (Cancer Center Amsterdam)
- joint VUmc/AMC PhD project from ACS (Amsterdam Cardiovascular Sciences)
- British Heart Foundation [PG/10/50/28434, PG/13/24/30115, PG/14/18/30724, PG/17/15/32845]
- St George's Hospital Charity [16.03.05]
- National Heart, Lung, and Blood Institute [R01HL080472]
- American Heart Association [18CSA34080399]
- RRM Charitable Fund
- ERC [692511]
- British Heart Foundation
- European Research Council (ERC) [692511] Funding Source: European Research Council (ERC)
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Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.
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