Journal
CANCER RESEARCH
Volume 79, Issue 14, Pages 3536-3538Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-19-1205
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Epithelial-to-mesenchymal transition (EMT) is orchestrated by aberrant activation of EMT transcription factors and expression of downstream target genes resulting in increased tumor initiation, metastatic potential, and therapeutic resistance. In this issue of Cancer Research, Wang and colleagues show that the long noncoding RNA SATB2-AS1 is dysregulated in colorectal carcinoma and correlates with poor survival and prognosis. They present a new functional mechanism illustrating how the SATB2-AS1-SATB2-Snail axis is involved in epigenetic modification that regulates colorectal carcinoma progression.
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