Journal
CANCER LETTERS
Volume 452, Issue -, Pages 132-143Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.03.020
Keywords
Cancer; ROS; Hypoxia Re-Oxygenation
Categories
Funding
- Carroll W. Feist endowed Chair Funds
- FWCC
- VA Merit Award [1BX001258]
- NCI [RO1-CA161880]
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Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability and the maintenance of redox homeostasis can cumulatively contribute to tumor progression and metastasis. The sources and the role of ROS in a heterogeneous tumor microenvironment can vary at different stages of tumor: initiation, development, and progression, thus making it a complex subject. In this review, we have summarized the sources of ROS generation in cancer cells, its role in the tumor microenvironment, the possible functions of ROS and its important scavenger systems in tumor progression with special emphasis on solid tumors.
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