Journal
CANCER LETTERS
Volume 451, Issue -, Pages 136-141Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.02.051
Keywords
microRNA; NF-kappa B; Neutrophils; Macrophages; OncomiR; Tumor suppressor
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Funding
- National Institutes of Health [R35GM119787]
- Purdue University Cagiantas fellowship
- Purdue Research Foundation Grant
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miR-223 is an evolutionarily conserved anti-inflammatory microRNA primarily expressed in myeloid cells. miR-223 post-transcriptionally regulates many genes essential in inflammation, cell proliferation, and invasion. Recent studies show that miR-223 is either endogenously expressed or transferred in exosomes or extracellular vesicles to non-phagocytic cells including cancer cells, where it exerts biological functions. In cancerous cells, miR-223 acts either as an oncomiR promoting tumors or as a tumor suppressor in a context-dependent manner. Taken together, miR-223 can regulate tumorigenesis at multiple levels, including by suppressing the inflammatory tumor microenvironment and modulating malignancy of cancer cells.
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