Journal
BIOMATERIALS
Volume 53, Issue -, Pages 609-620Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.02.124
Keywords
Angiogenesis; Cell culture; ECM; Hydrogel; Heparin; Carcinogenesis
Funding
- Endeavour Awards as part of the Prime Minister's Australia Awards
- German Research Foundation (Deutsche Forschungsgemeinschaft) [SFB-TR 67, WE 2539-7, FOR/EXC999]
- Leibniz Association [SAW-2011-IPF-2 68]
- European Union through the Integrated Project ANGIOSCAFF (Seventh Framework Program)
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Tumour microenvironment greatly influences the development and metastasis of cancer progression. The development of three dimensional (3D) culture models which mimic that displayed in vivo can improve cancer biology studies and accelerate novel anticancer drug screening. Inspired by a systems biology approach, we have formed 3D in vitro bioengineered tumour angiogenesis microenvironments within a glycosaminoglycan-based hydrogel culture system. This microenvironment model can routinely recreate breast and prostate tumour vascularisation. The multiple cell types cultured within this model were less sensitive to chemotherapy when compared with two dimensional (2D) cultures, and displayed comparative tumour regression to that displayed in vivo. These features highlight the use of our in vitro culture model as a complementary testing platform in conjunction with animal models, addressing key reduction and replacement goals of the future. We anticipate that this biomimetic model will provide a platform for the in-depth analysis of cancer development and the discovery of novel therapeutic targets. (C) 2015 Elsevier Ltd. All rights reserved.
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