Journal
BRITISH JOURNAL OF NUTRITION
Volume 122, Issue 6, Pages 616-624Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114519001508
Keywords
Intra-uterine growth restriction; Insulin resistance; Lipid metabolism; Curcumin; Rats
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Funding
- National Natural Science Foundation of China [31572418, 31802101, 31472129, 31601948]
- National key research and development programme of China [2018YFD0501101]
- Fundamental Research Funds for the Central Universities [KJQN201935]
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The objective of the present study was to investigate the effect of curcumin on insulin resistance (IR) and hepatic lipid accumulation in intra-uterine growth restriction (IUGR). Rats with a normal birth weight (NBW) or IUGR were fed basic diets (NBW and IUGR groups) or basic diets supplemented with curcumin (NBW-C and IUGR-C groups) from 6 to 12 weeks. Rats in the IUGR group showed higher levels of glucose and homeostasis model assessment for insulin resistance index (HOMA-IR) (P < 0 center dot 05) than in the NBW group. The livers of IUGR rats exhibited higher (P < 0 center dot 05) concentration of TAG and lower (P < 0 center dot 05) activities of lipolysis enzymes compared with the normal rats. In response to dietary curcumin supplementation, concentrations of serum insulin, glucose and HOMA-IR, pyruvate, TAG, total cholesterol and NEFA in the liver were decreased (P < 0 center dot 05). The concentrations of glycogen and activities of lipolysis enzymes in the liver were increased (P < 0 center dot 05) in the IUGR-C group compared with the IUGR group. These results were associated with lower (P < 0 center dot 05) phosphorylated insulin receptor substrate 1, protein kinase B or Akt, glycogen synthase kinase 3 beta and expressions of sterol regulatory element binding protein 1 and fatty acid synthase (FASN); decreased expressions for Cd36, sterol regulatory element binding protein 1c (Srebf1) and Fasn; increased (P < 0 center dot 05) expression of PPAR alpha; and expressions for Ppara and hormone-sensitive lipase in the liver of IUGR-C rats than the IUGR rats. Maternal malnutrition caused IR and lipid accumulation in the liver. Curcumin supplementation prevented IR by regulating insulin signalling pathways and attenuated hepatic lipid accumulation.
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