Journal
BIOMATERIALS
Volume 53, Issue -, Pages 127-136Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.02.086
Keywords
Anti-adhesion; Lubricin; Non-specific binding; Biofouling; Quartz crystal microbalance; Surface treatment
Funding
- Australian Research Council through a Discovery Early Career Research Award [DE130101458]
- ARC
- Australian Research Council [DE130101458] Funding Source: Australian Research Council
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Lubricin is a glycoprotein found in articular joints which has been recognized as being an important biological boundary lubricant molecule. Besides providing lubrication, we demonstrate, using a quartz crystal microbalance, that lubricin also exhibits anti-adhesive properties and is highly effective at preventing the non-specific adsorption of representative globular proteins and constituents of blood plasma. This impressive anti-adhesive property, combined with lubricin's ability to readily self-assemble to form dense, highly stable telechelic polymer brush layers on virtually any substrates, and its innate biocompatibility, makes it an attractive candidate for anti-adhesive and anti-fouling coatings. We show that coatings of lubricin protein are as effective as, or better than, self-assembled monolayers of polyethylene glycol over a wide range of pH and that this provides a simple, versatile, highly stable, and highly effective method of controlling unwanted adhesion to surfaces. (C) 2015 Elsevier Ltd. All rights reserved.
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