Journal
BRAIN IMAGING AND BEHAVIOR
Volume 14, Issue 5, Pages 1933-1944Publisher
SPRINGER
DOI: 10.1007/s11682-019-00137-0
Keywords
ADHD; Methylphenidate; Cognitive training; fMRI; Neuroimage
Categories
Funding
- Fundacao de Amparo a pesquisa do Estado do RS (FAPERGS) [0433-2551/14-0]
- AttentionDeficit/Hyperactivity Disorder Outpatient Program (ProDAH)
- Fundo de Incentivo a Pesquisa e Eventos do Hospital de Clinicas de Porto Alegre (FIPE-HCPA) [CAAE 25048913.8.0000.5327]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- UFGRS PROBIC-FAPERGS -a scientific initiation scholarship
Ask authors/readers for more resources
The neurofunctional effects of Cognitive training (CT) are poorly understood. Our main objective was to assess fMRI brain activation patterns in children with ADHD who received CT as an add-on treatment to stimulant medication. We included twenty children with ADHD from a clinical trial of stimulant medication and CT (10 in medication + CT and 10 in medication + non-active training). Between-group differences were assessed in performance and in brain activation during 3 fMRI paradigms of working memory (N-back: 0-back, 1-back, 2-back, 3-back), sustained attention (Sustained Attention Task - SAT: 2 s, 5 s and 8 s delays) and inhibitory control (Go/No-Go). We found significant group x time x condition interactions in working memory (WM) and sustained attention on brain activation. In N-back, decreases were observed in the BOLD signal change from baseline to endpoint with increasing WM load in the right insula, right putamen, left thalamus and left pallidum in the CT compared to the non-active group; in SAT - increases in the BOLD signal change from baseline to endpoint with increasing delays were observed in bilateral precuneus, right insula, bilateral associative visual cortex and angular gyrus, right middle temporal, precentral, postcentral, superior frontal and middle frontal gyri in the CT compared to the non-active group. CT in ADHD was associated with changes in activation in task-relevant parietal and striato-limbic regions of sustained attention and working memory. Changes in brain activity may precede behavioral performance modifications in working memory and sustained attention, but not in inhibitory control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available