Journal
BIOMATERIALS
Volume 44, Issue -, Pages 91-102Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.12.035
Keywords
Microcapsule; Microwave; Thermal therapy; Sodium alginate; Tumor
Funding
- National Hi-Technology Research and Development Program (863 Program) [2013AA032201, 2012AA022701]
- National Natural Science Foundation of China (NSFC) [61171049, 30800258, 20873171, 30900349]
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This work develops a kind of sodium alginate (SA) microcapsules as microwave susceptible agents for in vivo tumor microwave thermal therapy for the first time. Due to the excellent microwave susceptible properties and low bio-toxicity, excellent therapy efficiency can be achieved with the tumor inhibiting ratio of 97.85% after one-time microwave thermal therapy with ultralow power (1.8 W, 450 MHz). Meanwhile, the mechanism of high microwave heating efficiency was confirmed via computer-simulated model in theory, demonstrating that the spatial confinement efficiency of microcapsule walls endows the inside ions with high microwave susceptible properties. This strategy offers tremendous potential applications in clinical tumor treatment with the benefits of safety, reliability, effectiveness and minimally invasiveness. (C) 2014 Elsevier Ltd. All rights reserved.
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