Journal
BIOSCIENCE REPORTS
Volume 39, Issue -, Pages -Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BSR20190621
Keywords
-
Categories
Funding
- National Key Research and Development Program of China [2016YFC0905900]
- National Natural Science Foundation of China [81872365]
- '333' Talent Project of Jiangsu Province [4(2016)]
- Innovation Team Construction Project of Nanjing Medical University [JX102GSP201727]
Ask authors/readers for more resources
Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer deaths among females worldwide. Circular RNAs (circRNAs) are a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of regulating gene expression at transcription or post-transcription levels. With the unique structures, circRNAs are resistant to exonuclease RNase R and maintain stability more easily than linear RNAs. Recently, an increasing number of circRNAs are discovered and reported to show different expression in BCa and these dysregulated circRNAs were correlated with patients' clinical characteristics and grade in the progression of BCa. CircRNAs participate in the bioprocesses of carcinogenesis of BCa, including cell proliferation, apoptosis, cell cycle, tumorigenesis, vascularization, cell invasion, migration as well as metastasis. Here we concentrated on biogenesis and function of circRNAs, summarized their implications in BCa and discussed their potential as diagnostic and therapeutic targets for BCa.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available