Journal
BIOSCIENCE REPORTS
Volume 39, Issue -, Pages -Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BSR20190384
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Funding
- National Natural Science Foundation of China [81871317]
- Technology Innovation Nursery Fund of Chinese PLA General Hospital [16KMM15]
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The wide application of oncolytic adenovirus presents a novel therapeutic strategy for breast cancer gene therapy. Application of adenovirus alone achieves little curative effects on breast cancer. In addition, it is worth exploring the synergistic anti-tumor effect by inserting immunomodulatory factor in oncolytic adenovirus genome. By taking the advantage of the highly proliferative property of breast cancer, a novel recombinant adenovirus which could selectively kill tumor cells is established under an E2F-1 promoter. Also by carrying human Interleukin-15 (IL-15) gene, the oncolytic adenovirus exhibits an immunomodulatory effect. The present study proved that the novel oncolytic virus (SG400-E2F/IL-15) exhibits an enhanced anti-tumor activity both in vitro and in vivo, representing an experimental basis for breast cancer virus-gene therapy.
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