Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 29, Issue 13, Pages 1593-1596Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2019.04.051
Keywords
Sponge-derived fungus; Aspergillus sp.; gamma-Lactone; Lateral root growth; Cytotoxicity; AChE
Categories
Funding
- National Key Research and Development Program of China [2018YFC0310900]
- National Natural Science Foundation of China, China [41776168, 41706167]
- Natural Science Foundation of Zhejiang Province, China [LQ18C010001]
- Ningbo Public Service Platform for High-Value Utilization of Marine Biological Resources [NBHY-2017-P2]
- Zhejiang Provincial Public Welfare Technology Program [LGC19B020002]
- Natural Science Foundation of Ningbo, China [2018A610303, 2018A610320]
- National 111 Project of China [D16013]
- Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund
- K.C. Wong Magna Fund in Ningbo University
- Ningbo Sci. & Tech. Projects for Common Wealth [2017C10016]
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Two new gamma-lactones, aspergilactones A (1) and B (2), were discovered along with two known compounds, annularin A (3) and pericoterpenoid A (4), from a culture of the sponge-associated fungus Aspergillus sp. LS45. The planar structures of 1-4 were characterized using comprehensive spectroscopic methods and comparison with literature data. The absolute configurations of 1 and 2 were determined by comparison of electronic circular dichroism (ECD) spectroscopic and optical rotation data with those of known analogues as well as calculated ECD analysis. Compounds 1-4 were tested in a variety of bioassays, and both 1 and 4 exhibited significant inhibition against the lateral root growth of Arabidopsis thaliana Columbia-0 at a concentration of 100 mu M. In addition, the in vitro cytotoxic activities of 1-4 against six human cancer cell lines CCRF-CEM, K562, BGC823, AGS, HCT-116 and MDA-MB-231 were evaluated. Compound 4 showed moderate inhibitory effects on CCRF-CEM and K562 cancer cell lines with IC50 values of 13.8 +/- 1.6 and 12.9 +/- 2.5 mu M, respectively. However, compounds 1-4 did not show any notable AChE inhibitory activity in vitro.
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