Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 29, Issue 19, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2019.06.061
Keywords
Golgi; Secretion; Brefeldin A; Bisindole; High-throughput screening
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Funding
- JSPS KAKENHI of MEXT (Ministry of Education, Sport, Culture, Science and Technology in Japan) [23570167, 26440055, 18K06133]
- Futaba Electronics Memorial Foundation
- Grants-in-Aid for Scientific Research [26440055, 18K06133, 23570167] Funding Source: KAKEN
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To increase the chances of finding new candidate molecules with medicinal properties, while expending less resource and effort, the present study used pooled substrates as starting materials. A bisindole compound that showed inhibitory activity was then isolated from the mixture, and the activity was improved by optimizing the substituents on the indole skeleton.
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