Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 115, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2019.108912
Keywords
MSCs; Osteogenic differentiation; lncRNA; Bone formation and bone regeneration; Bone tissue engineering
Funding
- National Natural Science Foundation of China [81560452, 81672866]
- Natural Science Foundation of Jiangxi Province [20161BAB205192, 20171ACB21073]
- Youth Science Foundation of Jiangxi Province [20122BAB215028]
- Excellent Youth Foundation of Jiangxi Scientific Committee [20162BCB23001]
- Science and Research Fund of Jiangxi Health and Family Planning Commission [20164002]
- Foundation of Nanchang Science and Technology Bureau [2016 ZSCX009]
- The Yuanhang Project of Jiangxi Province
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Mesenchymal stem cells (MSCs) have the ability to differentiate into multiple cell types, including osteogenic, chondrogenic and adipogenic lineages. Osteogenic differentiation of MSCs plays a critical role in bone tissue engineering. Inducing MSC osteogenesis represents a potential treatment that promotes bone formation and bone regeneration. Recently, long non-coding RNA (lncRNA) was shown to participate in the occurrence and development of various diseases. Different lncRNA expression patterns can regulate the cell cycle, proliferation, metastasis, immunobiology and differentiation. With the recent extensive study of lncRNAs, an increasing number of lncRNAs are being studied in the MSC field. Furthermore, some lncRNAs have been confirmed to regulate MSC osteogenesis. Therefore, here, we review research concerning lncRNA in osteogenic differentiation of MSCs and highlight the importance of lncRNA in bone formation and bone regeneration.
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