Journal
BIOMARKERS IN MEDICINE
Volume 13, Issue 8, Pages 627-637Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2018-0404
Keywords
gamma-GT; ALT; AP mice; AR42J; gall stones; hyperlipemia; PACI; S1P; serum calcium; SPHK2
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Funding
- National Natural Science Foundation of China [81572738, 81800576]
- Natural Science Foundation of Guangxi [2015GXNSFEA139003]
- Lijiang Scholar Award in Guilin
- High Level of Innovation Team and Outstanding Scholars Program in Colleges and Universities in Guangxi
- Hundred Talents Program 'the Introduction of Overseas High-Level Talents in Colleges and Universities in Guangxi'
- recruitment program for the Affiliated Hospital of Guilin Medical University
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Aim: The roles of S1P in acute pancreatitis (AP) or non-AP patients with pancreatic acinar cell injury (PACI) are not well understood. Materials & methods: Serum S1P, in 40 healthy individuals and 99 patients with PACI, was retrospectively analyzed. Additionally, we detected and analyzed S1P in AP mice and the AR42J acinar cell line. Results: Serum S1P was significantly decreased in PACI patients, compared with that of healthy controls. Patients with gall stones, normal serum calcium or normal blood lipids showed relative higher levels of serum S1P. Interestingly, in patients with gall or liver disease, serum S1P was positively associated with gamma-GT and ALT. Additionally, S1P and SPHK2 were decreased in AP mice and AR42J cells, relative to the levels of corresponding controls. Conclusion: Serum S1P is decreased in PACI, which may be partly due to downregulation of pancreatic SPHK2.
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