Journal
BIOMACROMOLECULES
Volume 20, Issue 8, Pages 3057-3069Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.9b00629
Keywords
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Funding
- National Natural Science Foundation of China [51433007, 51673125, 51773127, 51803131, 51803134, 51873115]
- State Key Research Development Programme of China [2016YFC1103000, 2018YFC1106400]
- Science and Technology Program of Sichuan Province [2017SZ0011, 2019YJ0132]
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Nonadherent wound dressings with moisture management and long-lasting antibacterial properties have great significance for wound healing clinically. Herein, a novel multicomponent zwitterionic gradational membrane is fabricated by a co-electrospinning method to - realize low-biofouling and favorable moisture control as well as long-acting antibacterial properties during the chronic wound-healing process. The obtained membrane possesses excellent anti-biofouling performance that effectively resists protein, bacteria, and cell adhesion according to in vitro antifouling evaluation. Furthermore, the gradational co-electrospinning method grants the composite membrane with moisture retention capability which could effectively absorb wound exudate and maintain a moisture healing environment. Additionally, in vivo and in vitro antibacterial investigations reflect that the composite membrane has excellent long-acting antibacterial property. Moreover, in vivo wound healing assessment confirms that the prepared membrane significantly reduces the complete wound healing time than commercial wound dressing. These results highlight such a zwitterionic gradational membrane as an advanced wound dressing to meet the various requirements for chronic wound infection and skin tissue regeneration in clinical applications.
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