Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 194, Issue 2, Pages 313-320Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-019-01783-7
Keywords
Chromium; Coronary heart disease; Metabolic status; Type 2 diabetes mellitus
Funding
- Kashan University of Medical Sciences (KAUMS)
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This investigation was conducted to determine the effects of chromium supplementation on metabolic status in diabetic patients with coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed in 64 diabetic patients with CHD between October 2017 and January 2018. Patients were randomly divided into two groups to obtain either 200 mu g chromium (n = 32) or placebo (n = 32) for 12 weeks. Chromium supplementation significantly reduced body weight (- 0.9 +/- 1.6 vs. + 0.1 +/- 0.8 kg, P = 0.001), BMI (- 0.4 +/- 0.7 vs. + 0.1 +/- 0.3 kg/m(2), P = 0.002), fasting glucose (beta - 11.03 mg/dL; 95% CI, - 18.97, - 3.09; P = 0.007), insulin (beta - 1.33 mu IU/mL; 95% CI, - 1.90, - 0.76; P < 0.001), and insulin resistance (beta - 0.44; 95% CI, - 0.62, - 0.25; P < 0.001) and significantly increased insulin sensitivity (beta 0.007; 95% CI, 0.003, 0.01; P < 0.001) compared with the placebo. In addition, taking chromium led to a significant reduction in serum high-sensitivity C-reactive protein (hs-CRP) (beta - 0.49 mg/L; 95% CI, - 0.91, - 0.06; P = 0.02) and plasma malondialdehyde (MDA) levels (beta - 0.22 mu mol/L; 95% CI, - 0.35, - 0.10; P = 0.001); also, a significant rise in total antioxidant capacity (TAC) (beta 84.54 mmol/L; 95% CI, 31.05, 138.02; P = 0.002) was observed in comparison with placebo. Additionally, chromium administration significantly reduced diastolic blood pressure (DBP) (beta - 5.01 mmHg; 95% CI, - 9.04, - 0.97; P = 0.01) compared with the placebo. Overall, the 12-week supplementation of chromium to diabetic patients with CHD had beneficial impacts on weight, BMI, glycemic control, hs-CRP, TAC, MDA, and DBP.
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