Journal
BIOLOGICAL PSYCHOLOGY
Volume 145, Issue -, Pages 198-210Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.biopsycho.2019.03.019
Keywords
Fear conditioning; Connectivity; Amygdala; Adolescent; Parenting
Funding
- Canadian Institutes for Health Research (CIHR) [MOP-97983, MOP-44072, HDF-70335]
- Quebec Government's Ministry of Health
- Fonds Quebecois de la Recherche sur la Societe et la Culture (FQRSC)
- Canada's Social Science and Humanities Research Council (SSHRC)
- CHU Ste-Justine's Research Center
- University of Montreal
- Universite Laval
- FRSQ
- CIHR
- Canada Research Chair Program
- Fonds de recherche en sante du Quebec (FRSQ)
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002781] Funding Source: NIH RePORTER
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Previous studies have reported altered fear circuitry function during fear conditioning in highly anxious individuals and in adults with a history of severe childhood adversity; less is known regarding younger populations and more common forms of adversity. We investigated fear circuitry functioning in healthy youths with histories of high (HH) or low (LH) chronic harsh parenting and high (HA) or low (LA) anxiety levels. 84 youths aged 13-16 performed an fMRI fear conditioning task. HH displayed decreased selective medial temporal lobe de-activations to CS + > CS - relative to LH. In addition, we found less amygdala-insula connectivity in HH vs LH. Interestingly, we observed distinct patterns of anxiety differences in amygdala-rostral ACC connectivity and subjective fear ratings depending on harsh parenting levels, suggesting a history of harsh parenting is linked with unique neural and behavioral anxious manifestations, which are different from anxiety manifestations in a context of low adversity.
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